Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

By artappraiser on Thu, 10/29/2020 - 1:41am |

I have seen recent spate of contrarian buzz on antibodies, so I thought this worth a post as not a small sample!. Link is to the full PDF but you can see first page with highlighting in tweet below

Just published @ScienceMagazine. >30,000 people w/mild to moderate #COVID19 have excellent IgG antibody titers for several months. No disappearing act. Importanthttps://t.co/4kCZY8qcmo @MountSinaiNYC @FatimaAmanat @DrDavidReich @florian_krammer @IcahnMountSinai et al
, pic.twitter.com/B3LJ6JaBDa
— Eric Topol (@EricTopol) October 28, 2020

URL:

https://science.sciencemag.org/content/sci/early/2020/10/27/science.abd7728.full.pdf

Add new comment
4219 reads

Comments

How to let the virus win.
The hospitalizations are climbing quickly.
Deaths >1000.
And no action taken to achieve a semblance of controlhttps://t.co/w1z64Gj3x6 pic.twitter.com/XId89F8cYD
— Eric Topol (@EricTopol) October 28, 2020

We haven't see positive testing rates like this at any point during the US pandemic. Overall US positive test rate has shot up to 7.3%, and testing has decreased.

South Dakota 43.4%
Idaho 34.8%
Wyoming 31.5%
Wisconsin 28.0%
Iowa 26.4%
Alabama 25.2%
Nebraska 21.8%
Kansas 20.7%
— Eric Topol (@EricTopol) October 28, 2020

Above data from https://t.co/BuuW28dyJl
Graph @OurWorldInData on 3rd spike in positive tests pic.twitter.com/GqWRZEfcc4
— Eric Topol (@EricTopol) October 28, 2020

What happens when you have such extremely high positive test rates?
This. Via the sharp @thehowie https://t.co/7Jzl8GlHEC
— Eric Topol (@EricTopol) October 28, 2020

also a reminder that health care workers catch it the same time other people are catching it!

Hospital admissions for #COVID19 in Scotland:
1 in 6 (17%) were healthcare workers and their families.
3X for patient-facing personnel.
Notable high risk in paramedics and ED personnel "front door" roles.https://t.co/CLhI8UthKZ Just out @bmj_latest pic.twitter.com/m1aFQydPu1
— Eric Topol (@EricTopol) October 28, 2020

by artappraiser on Thu, 10/29/2020 - 1:48am

gonna be cold outside > what to do?

Very helpful info for understanding what needs to be done about the virus. https://t.co/X6Wt2FVmTt
— Erich Luepke (@erich_luepke) October 29, 2020

by artappraiser on Thu, 10/29/2020 - 1:50am

1. Antibodies drop to baseline titers that are undetectable by commonly used serology assays. There are still low levels of antibody as well as memory B cells that can rapidly produce more antibody in the event of re-exposure (anamnestic response).

This is not "waning immunity"
— Dr. Angela Rasmussen (@angie_rasmussen) October 27, 2020

3. Some people (possibly with mild infection) do not have long-lasting antibodies for whatever reason. They do not have sufficient memory B cells to mount an effective anamnestic response.

This is "waning immunity"
— Dr. Angela Rasmussen (@angie_rasmussen) October 27, 2020

However, this should underscore the fact that "natural herd immunity" is not the way to go. There are too many unknowns to choose this as a safer, easier path to population immunity vs a vaccine that undergoes rigorous evaluation in controlled trials.
— Dr. Angela Rasmussen (@angie_rasmussen) October 27, 2020

https://t.co/lBjpP49xTa
— Tom Andrews (@WeVotedToLeave) October 27, 2020

Several studies have seen 90%+ of persistence of IgG up to 4/6 months after the infection. Could this one have seen a lower percentage due to lower threshold for the used test in that study?
— LoupDesVosges (@LDVRegainSyb) October 27, 2020

Others have found the important, neutralizing antibodies drop after 4-5 weeks.https://t.co/EQzkW8zXxw
— LASER Death Ray Truant PhD (@RayTruant) October 27, 2020

by PeraclesPlease on Thu, 10/29/2020 - 3:30am

How vaccines work thread

Live attenuated vaccines worked well by themselves. But, immunization using toxoid alone induced poor immunity. #GastonRamon found that toxoid injected with ‘stuff’ incl. tapioca, lecithin, agar, starch oil, saponin or breadcrumbs improved immunity. (2/n)https://t.co/K73osL5abq
— Prof. Akiko Iwasaki (@VirusesImmunity) October 16, 2020

Reinfection thread

1) Second infection was asymptomatic. While immunity was not enough to block reinfection, it protected the person from disease. (2/n) pic.twitter.com/C65F8ff5UN
— Prof. Akiko Iwasaki (@VirusesImmunity) August 24, 2020

And a rather strange writeup on discrimination against this scientist who "was just 30 when she established her lab at Yale. She was granted tenure and an appointment at Howard Hughes Medical Institute within the next decade, both of which freed her up to take on non-lab projects, such as her science communication efforts, and to cultivate a lab environment that’s considerate of everyone. And in the last two years, she has been elected to both the National Academy of Sciences and the National Academy of Medicine, dual recognitions that are reserved for the most accomplished scientists."
I mean, yes, academia has a pecking order, so those on the top often look down on those below. I can imagine there's discrimination, including "micro-discrimination", but I know I've had ideas rejected pretty harshly in a professional environment (as well as not been able to penetrate the glass ceiling of "unqualified lazy-AF execs with cherry connections"), and people will sometimes look funny at my kids, and they're white. People are tribal for many reasons besides just race. (And I've also worked around Asians, and they come in the complete gamut of very pleasant to very difficult, with all the usual complexities & variabilities)

OMG

Thank you so much @statnews @scchak for writing this article about me. It is not just a story about me, but of the brave and brilliant people who I surround myself with. This is a story of every #womeninSTEM. https://t.co/g2DhHTkz7a via
— Prof. Akiko Iwasaki (@VirusesImmunity) October 27, 2020

by PeraclesPlease on Thu, 10/29/2020 - 4:03am

Ditto the above to include Asian females. Including one who was in the inner circle who might have been as much focused on very successful ladder-climbing as solid professionalism, one who was always complaining & had politics that differed from mine but seemed to do solid work, one who was a bit shy but hard working and seemed appreciated & well-promoted, a variety of other execs and rank & file members.

by PeraclesPlease on Thu, 10/29/2020 - 4:13am

One of the largest studies of Covid-19 prevalence in England showed cases are now doubling every nine days https://t.co/ePToy50Ad9
— Financial Times (@FinancialTimes) October 29, 2020

by artappraiser on Thu, 10/29/2020 - 3:34am

The new variant, which has six distinctive genetic mutations, emerged among agricultural workers in north-east Spain in June and moved quickly through the local population, according to the study.
via @FT ⁦@clivecookson⁩
https://t.co/9gPNn6WVDB
— Anne-Sylvaine Chassany (@ChassNews) October 29, 2020

Haven't read it (firewall) but useful to post the tweet to track more accessible info. later.

by artappraiser on Thu, 10/29/2020 - 4:06am

BREAKING—US has now surpassed 9,000,000 cases of #COVID19.

Accelerated since last month—newest mil only took 14 days.

1 mil April 28
2 mil June 10
3 mil July 7
4 mil July 23
5 mil Aug 8
6 mil Aug 30
7 mil Sept 25
8 mil Oct 15
9 mil Oct 29 pic.twitter.com/IxN5SJnsBe
— Eric Feigl-Ding (@DrEricDing) October 29, 2020

by artappraiser on Thu, 10/29/2020 - 11:36pm

^ note animated graphic has Halloween/pandemic appropriate music

by artappraiser on Thu, 10/29/2020 - 11:39pm

worst week ever for the U.S.; deaths are rising again

The U.S. reported a record of more than a half million new coronavirus cases in the past week, with a large swath of the country experiencing their worst weeks yet.

Here’s our analysis of the most recent data from our database. https://t.co/4Z5MPZN7EJ
— The New York Times (@nytimes) October 30, 2020

Deaths from the coronavirus are rising again in the U.S. A leading expert blames, in part, "pandemic fatigue" - people are weary of hunkering down and are venturing out more. https://t.co/nTjaZGENjZ
— The Associated Press (@AP) October 26, 2020

by artappraiser on Fri, 10/30/2020 - 7:33pm

If you want to watch a real-life zombie movie, here you go: riots explode in Spain as people revolt against additional lockdown orders during a grave COVID situation.

(Also, Castilian Spanish lesson, as alarmed woman narrates the action.) https://t.co/EfjICuifYM
— Antonio García Martínez (@antoniogm) October 30, 2020

Edit to add later video from Burgos (turn sound on) and then molotov cocktails from Florence from same source

Chaos cette nuit à #Burgos contre l'instauration du #CouvreFeu. #COVID19 #ConfinementActe2 pic.twitter.com/RQ1055GT4z
— Anonyme Citoyen (@AnonymeCitoyen) October 30, 2020

- Les manifestants jettent des cocktails molotov en direction des forces de l'ordre à #Florence. Les affrontements durent puis plusieurs heures. #Firenze #COVID19 #ItaliaSiRibella pic.twitter.com/C4H7FLL6g2
— Anonyme Citoyen (@AnonymeCitoyen) October 30, 2020

by artappraiser on Fri, 10/30/2020 - 7:41pm

on point even though he doesn't know of the above:

I worry that a national mask mandate will inevitably lead to videos of overzealous enforcement that pour fuel on the fire of anti-lockdown protestors and undermine the broader goal of high rates of mask wearing. State and local ordinances plus voluntary compliance work well here.
— Samuel Hammond (@hamandcheese) October 31, 2020

also to consider: there's awful shit like this going on, it's like to be fair one has to let businesspeople judge their own risk about how hard whatever rules they choose will be to enforce. Alternately, if the government requires, they at least are covered by rule of law.

by artappraiser on Fri, 10/30/2020 - 8:12pm

The Professor is very depressed and would like us to share his depression, I guess:

Anyone believing that lockdowns then, now, forever, or never, are a silver bullet for #COVID19 may not fully grasp the complexity and multidimensional nature of the problem we're facing, not that there's been much progress in that respect for months.https://t.co/lWfd0oAXyG
— Prof Francois Balloux (@BallouxFrancois) October 30, 2020

In principle would you accept a form of lockdown can be effective in reducing transmission? As you say too many other factors to consider, but reducing transmission is the number one goal which lockdowns surely do help?
— Gus McLean (@GusM_LW) October 30, 2020

Lockdowns are sensible measures to avoid hospitals being overrun. That was the essence of the "flattening the curve" argument in the spring. It is a bit depressing than rather than building up capacity for the winter, we're back to square one, without any better long-term plan.
— Prof Francois Balloux (@BallouxFrancois) October 30, 2020

That I would wholeheartedly agree with, we should be in a better position than we are,for a variety of reasons we’re not. As undesirable as the measures are,they may be the best course of action in the current position.That & giving those who don’t take basic precautions a slap.
— Gus McLean (@GusM_LW) October 30, 2020

Isn't lockdown vs no lockdown a false choice? Masks and distancing until vaccine are the core concepts (I thought). If they don't happen, for whatever reason, lockdown is a last resort to save hospitals. What am I missing?
— Peter Harrison (@Villager1244) October 30, 2020

We knew that in the first place with the argentinian example (strong lockdown + universal masking). Not everyone is as precautious and equipped as in a P4 lab..
— S P (@toutvaencore) October 31, 2020

The same could be said for vaccines. I think if we were more accepting of the reality that 1st generation vaccines, while possibly reducing mortality and morbidity, are unlikely to halt transmission then we might think twice about serial lockdowns ad infinitum
— Dr Rashmi Patel (@RPatelDr) October 30, 2020

I agree. What I really wished is if we could have a society-wide adult discussion of what to do, once we've all accepted there's no pie in the sky, no cavalry coming, just hard choices and painful tradeoffs.
— Prof Francois Balloux (@BallouxFrancois) October 30, 2020

by artappraiser on Sat, 10/31/2020 - 5:10pm

Someone posted this about the Czech Republic later on his thread:

What are the other solutions for collapsing hospitals? https://t.co/rPAmVNkcwg
— Jiří Hudeček (@HuJirui) October 30, 2020

by artappraiser on Sat, 10/31/2020 - 5:11pm

Fauci's got the depression too:

“We’re in for a whole lot of hurt. It’s not a good situation,” Anthony S. Fauci, the country’s leading infectious-disease expert, said in a wide-ranging interview late Friday. “You could not possibly be positioned more poorly.” https://t.co/G3GZlDdthy
— Josh Mankiewicz (@JoshMankiewicz) November 1, 2020

by artappraiser on Sat, 10/31/2020 - 10:18pm

What will our health care system be like in a year? It was already a mess of stressed-out (some suicidal) people looking to switch careers before covid started.

by artappraiser on Sat, 10/31/2020 - 10:21pm

In the News

Russia plays weak hand in Palestine
Russia plays weak hand in Palestine

submitted by PeraclesPlease 10 months ago

The intra-Palestinian meeting in Moscow has precedent

Russia's hosted such meetings in the past, most recently Feb 2019

Russia has long lamented the US' "monopolization" of the peace process & tried to carve out a niche for itself: mediating among the disunited Palestinians/2
— Hanna Notte (@HannaNotte) February 29, 2024

Read the article at https://twitter.com/HannaNotte/status/1763116222256701787

Add new comment
Mother Jones is Reaching out to Alternative Party Voters
Mother Jones is Reaching out to Alternative Party Voters

submitted by HSG 10 months ago

Here's what I told them: https://halginsberg.com/vote-for-jill-stein-again/

Read the article at https://halginsberg.com/vote-for-jill-stein-again/

2 comments

Add new comment
Controversial Brazil law curbing Indigenous rights comes...
Controversial Brazil law curbing Indigenous rights comes into force

submitted by artappraiser 1 year ago

Controversial Brazil law curbing Indigenous rights comes into force https://t.co/pCoDg05irX
— Gareth Harris (@garethharr) December 28, 2023

Read the article at https://www.theguardian.com/world/2023/dec/28/brazil-law-indigenous-land-rights-claim-time-marker?CMP=share_btn_tw

1 comment

Add new comment
Security Alert: U.S. Embassy Port-au-Prince, Haiti (...
Security Alert: U.S. Embassy Port-au-Prince, Haiti (December 25, 2023)

submitted by artappraiser 1 year ago

Location: U.S. Embassy and residential compounds

Events: Heavy gunfire is occuring around the area of the U.S. Embassy and residential compounds adjacent to the Trutier area of Tabarre. All Embassy personnel have been instructed to remain indoors and shelter-in-place until further notice. All others should avoid the area.

Actions to take:

Avoid the area;

Avoid demonstrations and any large gatherings of people;

Do not attempt to drive through roadblocks; and

If you encounter a roadblock, turn around and get to a safe area.

Read the article at https://ht.usembassy.gov/security-alert-u-s-embassy-port-au-prince-haiti-december-25-2023/

3 comments

Add new comment
Pakistan Is Creating the World’s Next Refugee Crisis
Pakistan Is Creating the World’s Next Refugee Crisis

submitted by artappraiser 1 year ago

By The Editorial Board @ Bloomberg.com, December 8, 2023

A mass expulsion of Afghan migrants could destabilize the region and fuel radicalization. The West should pressure Islamabad to change course.

Read the article at https://www.bloomberg.com/opinion/articles/2023-12-08/pakistan-s-expulsion-of-afghan-refugees-risks-another-crisis

6 comments

Add new comment
Internet shut down in Chad
Internet shut down in Chad

submitted by artappraiser 1 year ago

All eyes on #Chad right now
Chad has two internet trunks coming into the country: One from the Red Sea via Sudan; the other from Cameroon. Not possible for the totality of the country's internet network to be shut unless done centrally. A lot of rumors swirling; few facts. https://t.co/N6bDJZ2ixO

Read the article at https://x.com/_hudsonc/status/1732891968709992511?s=20

2 comments

Add new comment
[Economy] where Joe's success falls short
[Economy] where Joe's success falls short

submitted by PeraclesPlease 1 year ago

Read the article at

3 comments

Add new comment
[CRIME News] 3 loss-prevention employees in Macy’s across...
[CRIME News] 3 loss-prevention employees in Macy’s across the street from Philadelphia City Hall stabbed

submitted by artappraiser 1 year ago

BREAKING: Three loss prevention employees in Macy’s across the street from Philadelphia City Hall stabbed, one of them has died from stab wounds, @PhillyPolice sources tell me. Police converged on the store as the three workers were rushed to Jefferson Hospital. pic.twitter.com/4U1eKycL4W

Read the article at https://x.com/KeeleyFox29/status/1731713272942940365?s=20

38 comments

Add new comment
Former U.S. Ambassador Arrested, Charged With Working As...
Former U.S. Ambassador Arrested, Charged With Working As Secret Agent For Cuba

submitted by artappraiser 1 year ago

Former US Ambassador Arrested, Charged With Working As Secret Agent For Cuba https://t.co/LDwo4ZJI1K
— HuffPost (@HuffPost) December 4, 2023

Read the article at https://www.huffpost.com/entry/manuel-rocha-ambassador-arrested-cuba_n_656d1e2ae4b028b0f3d07478

Add new comment
[War in Israel, Chapter II] UNRWA under scrutiny
[War in Israel, Chapter II] UNRWA under scrutiny

submitted by artappraiser 1 year ago

[Chapter I news is HERE, Oct. 7 til today]

You don’t get it.
It’s not about an UNRWA teacher who held an Israeli kid hostage in his house.
It’s all about how for 75 years you have destroyed the future of generations of Palestinians, including my family.
My cousins in Arab countries are still not citizens - not even the… https://t.co/nv6anubGhc
— George Deek (@GeorgeDeek) December 2, 2023

Note 'Community Notes' attached to UNWRA's statement.

Read the article at https://x.com/GeorgeDeek/status/1731020551328579863?s=20

58 comments

Add new comment
Maduro, Under Pressure, Holds Vote to Annex Territory From...
Maduro, Under Pressure, Holds Vote to Annex Territory From a Neighbor

submitted by artappraiser 1 year ago

Imperialism for me but not for thee?

It's wild that Venezuela is now holding a vote on whether 2/3 of Guyana actually belongs to them! Analysts suggest that Modoru may want military action to pump up his sinking popularity.

Could we have a war in South America?!?

"The people who live in Essequibo are largely… pic.twitter.com/QvMEjkkgwy

Read the article at https://www.nytimes.com/2023/12/03/world/americas/maduro-vote-essequibo-guyana.html

6 comments

Add new comment
[Where is the GOP headed?] Divisions leave Florida’s House...
[Where is the GOP headed?] Divisions leave Florida’s House Republicans powerless

submitted by artappraiser 1 year ago

The lack of a cohesive delegation has allowed attention-seeking lawmakers to act on their own.

McCarthy: “You have [Rep. Matt] Gaetz, who belongs in jail…”

Gaetz: “Tough words from a guy who sucker punches people in the back. The only assault I committed was against Kevin’s fragile ego.”https://t.co/LctPuz6Pcf

Read the article at https://www.politico.com/news/2023/11/29/divisions-leave-floridas-house-republicans-powerless-00129200

10 comments

Add new comment
‘She got so mad at me’: book on the ‘Squad’ details AOC-...
‘She got so mad at me’: book on the ‘Squad’ details AOC-Pelosi clashes

submitted by artappraiser 1 year ago

By Martinn Pengelly in Washington DC for TheGuardian.com, Nov. 30

Alexandria Ocasio-Cortez tells Ryan Grim life in Congress ‘completely transformed’ after Democratic leader stepped down

Read the article at https://www.theguardian.com/books/2023/nov/30/squad-book-aoc-nancy-pelosi?CMP=share_btn_tw

15 comments

Add new comment
US health insurers Humana, Cigna in talks to merge -source
US health insurers Humana, Cigna in talks to merge -source

submitted by artappraiser 1 year ago

@ Reuters, Nov. 29

Read the article at https://www.reuters.com/markets/deals/us-health-insurers-humana-cigna-talks-merge-wsj-2023-11-29/

3 comments

Add new comment
Central Africa’s dinosaur regimes and the art of coup-...
Central Africa’s dinosaur regimes and the art of coup-proofing

submitted by artappraiser 1 year ago

"Both the AU and the intl community place more weight on whether elections are held than whether they are free and fair. Sanctions/expulsions occur when there is a coup but not necessarily when elections are rigged or if an “institutional coup” occurs." https://t.co/m9dNimJP0D
— Cameron Hudson (@_hudsonc) November 28, 2023

Read the article at https://africanarguments.org/2023/11/central-africas-dinosaur-regimes-and-the-art-of-coup-proofing/

Add new comment

From the Readers

Creative corner

From the Dagbloggers

Hits of the Day